Dept. of Animal Sciences, Washington State University, Pullman, WA 99164
Immunosuppression in the Mouse by Porcine Uterine Secretory Protein*
Version of Record online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 1, Issue 4, pages 193–198, August 1981
How to Cite
ALLEN, R. L., MURRAY, F. A. and WIETSMA, H. T. (1981), Immunosuppression in the Mouse by Porcine Uterine Secretory Protein. American Journal of Reproductive Immunology, 1: 193–198. doi: 10.1111/j.1600-0897.1981.tb00036.x
Approved for publication as Journal Article No. 17–18 of the Ohio Agricultural Research and Development Center, Wooster. Upjohn and Co graciously supported a portion of this work.
- Issue online: 9 MAY 2013
- Version of Record online: 9 MAY 2013
- Accepted March 11, 1981
ABSTRACT: Experiments were performed to determine whether uterine secretory proteins (PAP) of the pig affect T cell or B cell functions in vivo. T cell functions examined were E-rosette formation (ERF) and cutaneous reactivity (to phytohemagglutinin) in mature BALB/c females. Two ERF experiments of identical design were performed using five groups of ten mice each. Each mouse was presensitized with sheep erythrocytes (SRBC) designated as day 0; and the various groups were treated with saline, pig serum (PS), or PAP at different times. For cutaneous reactivity, the area of erythema at the sensitization site (pinnea of ear) was measured, and three groups of 11 mice were used. These groups also received either PS or PAP. B cell function was examined by measurements of hemagglutination titers to SRBC sensitization in BALB/c females treated in two experiments similar to the ERF. T cell functions examined were highly suppressed (p < 0.01) by PAP given hours, not days, prior to the measurement. The B cell function examined was not affected by PAP.