This work was supported in part by the North West Cancer Research Fund, and was presented in part at the Second International S. B. Gusberg Symposium on Reproductive Immunology, New York, June 1981.
Human Trophoblast-Specific Surface Antigens Identified Using Monoclonal Antibodies*
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 1, Issue 5, pages 246–254, October 1981
How to Cite
JOHNSON, P. M., CHENG, H. M., MOLLOY, C. M., STERN, C. M. M. and SLADE, M. B. (1981), Human Trophoblast-Specific Surface Antigens Identified Using Monoclonal Antibodies. American Journal of Reproductive Immunology, 1: 246–254. doi: 10.1111/j.1600-0897.1981.tb00049.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted May 20, 1981
- monoclonal antibodies;
- trophoblast antigens;
- placental syncytiotrophoblast;
ABSTRACT: Mouse monoclonal antibodies have been produced against syncytiotrophoblast plasma membrane preparations isolated from term human placentas. Of 20 positive clones, two antibodies (H309, H318) were directed against the Cγ2 domain of IgG, one (H312) was directed against albumin, and another (H303) was directed against a further normal human serum component (not transferrin). One monoclonal antibody (H310) recognized an antigenic epitope restricted to trophoblast and lymphocytes: this antibody did not inhibit mitogenic or allogeneic stimulation of lymphocytes. Two monoclonal antibodies (H315 and H317) reacted with trophoblast-specific antigenic determinants. The H315 antigen was present on first trimester syncytiotrophoblast, unlike the H317 antigen.