Absence of T Cell-Mediated Cytotoxicity in Breast Cancer Patients Against A Breast Cancer-Derived Target Cell


ICRF Human Tumour Immunology Group, University College Hospital Medical School, University Street, London WC1E 6JJ, England.


ABSTRACT: Fresh E-rosette positive lymphocytes from normal donors are not cytotoxic for the breast cancer-derived target cell MDA-157, although they do lyse other suspension and monolayer targets. E-rosette positive cells from breast cancer patients in different stages of disease and from patients with benign breast disease also do not lyse MDA-157. This remains true even when an HLA-A or -B locus antigen is shared by effector and target cell. These data therefore provide no evidence for T cell sensitization in breast cancer patients.