This work was supported by Swiss National Science Foundation grant 3.489-0.79.
Lymphocyte Specificity to Protein Antigens. IV. In Vivo and In Vitro Activation of Cytochrome-Specific T Cells Is Dependent on Protein Conformation*
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 1, Issue 6, pages 322–325, December 1981
How to Cite
CORRADIN, G., CHILLER, J. M., ENGERS, H. D., BRON, C. and BÜCHMULLER, Y. (1981), Lymphocyte Specificity to Protein Antigens. IV. In Vivo and In Vitro Activation of Cytochrome-Specific T Cells Is Dependent on Protein Conformation. American Journal of Reproductive Immunology, 1: 322–325. doi: 10.1111/j.1600-0897.1981.tb00065.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted July 1, 1981
- Antigen presentation;
- T cell;
ABSTRACT: Data are presented that suggest that the activation of cytochrome c-specific T lymphocytes is dependent on the integrity of the three-dimensional structure of the protein antigen. These results were obtained both at the population level and at the clonal level. The capacity of the native and denatured forms of cytochrome c to activate a different set of T cell clones was observed both in vivo and in vitro. These results could be explained by the differential capacity of macrophages to process and/or present the two forms of cytochrome c.