Genetic Control of Autoantibody Production to Spermatozoa in Vasectomized Rats

Authors

  • TSUYOSHI TAKAMI,

    1. Department of Pathology, University of Connecticut Health Center, Farmington, and Department of Pathology, University of Pittsburgh School of Medicine
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  • HEINZ W. KUNZ,

    1. Department of Pathology, University of Connecticut Health Center, Farmington, and Department of Pathology, University of Pittsburgh School of Medicine
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  • THOMAS J. GILL III,

    1. Department of Pathology, University of Connecticut Health Center, Farmington, and Department of Pathology, University of Pittsburgh School of Medicine
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  • PIERLUIGI E. BIGAZZI MD

    Corresponding author
    1. Department of Pathology, University of Connecticut Health Center, Farmington, and Department of Pathology, University of Pittsburgh School of Medicine
      Department of Pathology, University of Connecticut Health Center, Farmington, CT 06032.
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  • This work was supported by contract 72–775 from the NICHHD and grant HD 08662 from the National Institutes of Health and was presented in part at the First S.B. Gusberg Seminar on Reproductive Immunology (Mount Sinai Medical Center), New York, June 1980.

Department of Pathology, University of Connecticut Health Center, Farmington, CT 06032.

Abstract

ABSTRACT: Previous studies from our laboratory using vasectomized rats of different inbred strains have suggested that MHC-linked genes do not play a major role in the formation of autoantibodies to spermatozoa. In the present paper, we demonstrate that sperm autoantibody production is not influenced by genes in the major histocompatibility complex, using vasectomized congenic rats and various crosses between high and low responder strains. We also show that autoimmune responses to spermatozoa are not influenced by genes on the Y-chromo-some.

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