This work was supported by grants from the Medical Research Council of Canada and the National Cancer Institute of Canada.
Thymic Hormone-Induced Accelerated Development of Antibody Responsiveness to Sheep Red Blood Cells in the Newborn Mouse*
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 2, Issue 2, pages 107–110, April 1982
How to Cite
TEODORCZYK-INJEYAN, J., POTWOROWSKI, E.F., BIANKI, S. and FALK, R.E. (1982), Thymic Hormone-Induced Accelerated Development of Antibody Responsiveness to Sheep Red Blood Cells in the Newborn Mouse. American Journal of Reproductive Immunology, 2: 107–110. doi: 10.1111/j.1600-0897.1982.tb00096.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted October 6, 1981
- T cell subsets;
- T cell ontogeny;
- thymic hormone;
- T suppressor;
- T helper
ABSTRACT: The influence of thymic preparations on the kinetics of the development of PFC response to sheep erythrocytes was tested in mice 0 to 4 weeks old. Soluble thymic factor (STF) or thymic epithelial culture supernatant (TES) was prepared from the thymuses of C57B1/6 mice. STF was injected to gravid mice on day 13 or on day 18 of gestation. A marked acceleration in the appearance of PFC to SRBC was noted only in the offspring from those mothers having received STF on day 18. The ability to generate anti-SRBC response in vitro by splenocytes from 1-to 4-week-old mice was significantly improved in the presence of TES. The accelerated appearance of the response to a T-dependent antigen is attributed to increase in the ratio of T helper/T suppressor cells resulting from differentiation and/or clonal expansion under the influence of STF crossing of the placental barrier in the materno-fetal direction.