Respective Roles and Interactions of T Lymphocyte and PGE2-Mediated Monocyte Suppressive Activities in Human Newborns and Mothers at the Time of Delivery
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 2, Issue 3, pages 127–134, June 1982
How to Cite
DURANDY, A., FISCHER, A., MAMAS, S., DRAY, F. and GRISCELLI, C. (1982), Respective Roles and Interactions of T Lymphocyte and PGE2-Mediated Monocyte Suppressive Activities in Human Newborns and Mothers at the Time of Delivery. American Journal of Reproductive Immunology, 2: 127–134. doi: 10.1111/j.1600-0897.1982.tb00153.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted January 15, 1982
- pregnant women;
- T lymphocyte suppressive activity;
- monocyte suppressive activity;
ABSTRACT: Recently the concept of a poorly functional humoral immune response in the newborn was proposed. Data have been presented indicating that the impaired newborn B cell maturation, as shown in vitro in a pokeweed mitogen-induced B cell maturation system, is due both to an immaturity of lymphocyte subsets and to an increased suppressive T activity. In the present work, we present evidence that there exists a predominance of a naturally occurring T lymphocyte suppressive activity in the cord blood in that the removal of the suppressive activity by irradiation allows a normal maturation of newborn B cells. Such normal maturation of newborn B cells can also be obtained using mixed cultures of adult T cells and newborn B cells. Newborn suppressor T cells belong to both EAγ(+) and EAγ(—) fractions, and it is not known whether these two groups do or do not belong to different subsets. The PGE2-dependent monocyte suppressive activity does not play any role in the suppression observed in newborns since newborn monocytes are poorly suppressive and since they produce a smaller amount of PGE2 than adult monocytes. Some observations suggest, on the contrary, that the suppressive T lymphocytes can regulate the level of the PGE2-dependent monocyte suppressive activity.
It should be noticed that similar observations about T lymphocyte and PGE2-dependent monocyte suppressive activities have been made at the same time using mothers' cells. These observations suggest the possibility that such changes in B cell immune regulation may result from an interaction between maternal and fetal lymphoid cells.