This work was supported by the National Health and Medical Research Council, the Danish Medical Research Council (grant #512-20627), and Direktor Jacob Madsens and Hustru Olga Madsens Fond. Some of the data in this manuscript was presented at the Immunology of the Placenta Symposium, Aberdeen, United Kingdom in 1981 and at the First Australian Congress in Obstetrics and Gynaecology in 1981.
Circulating C3, C4, and C3 Split Products (C3c and C3d) During Normal Pregnancy*
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 2, Issue 6, pages 309–311, December 1982
How to Cite
TEISNER, B., HAU, J., TUCKER, M., LAHOOD, J. and GRUDZINSKAS, J. G. (1982), Circulating C3, C4, and C3 Split Products (C3c and C3d) During Normal Pregnancy. American Journal of Reproductive Immunology, 2: 309–311. doi: 10.1111/j.1600-0897.1982.tb00198.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted June 21, 1982
- complement activation;
- split products
ABSTRACT: The plasma concentrations of the complement components C3 and C4, as well as the split products C3c and C3d, were measured before, during, and after normal pregnancy. Significantly increased values were observed in the C3 and C3d levels in the second and third trimesters of pregnancy. The level of C4 was not significantly affected by pregnancy and C3c could not be detected using electroimmunoassays. These results suggest that the increased C3 split-product levels observed reflected an increased turnover of native C3 rather than activation of the complement cascade.