Demonstration That Milk Cells Invade the Suckling Neonatal Mouse


  • This work was presented at the Third International Symposium on the Irnmunology of Reproduction, Winston-Salem, North Carolina, June 24–26, 1982

Immunology Unit, University of Konstanz, D-7750 Konstanz, Federal Republic of Germany.


ABSTRACT: Mouse milk cells were stained with rhodamine or fluorescein isothiocyanate and fed to young suckling mice. By visual examination of serial sections and by flow cytofluorometry, we were able to demonstrate directly the presence of these cells in peripheral tissues.

It was estimated that at least 0.1% of the fed cells might infiltrate the young mouse, which is initially immunologically defenseless. This is in accordance with evidence from many sources for activity of maternally-derived lymphoid cells in young rodents.