Immune Monitoring of Pregnancy in Renal Transplanted Patients

Authors

  • S.A. BIRKELAND MD,

    Corresponding author
    1. Tissue Culture Laboratory, Odense University Hospital, Odense, Denmark
    2. Institute of Pathology, Department of Nephrology, Odense University Hospital, Odense, Denmark
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  • K. KRISTOFFERSEN

    1. Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
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Department of Nephrology, Odense University Hospital, DK-5000 Odense C, Denmark.

Abstract

ABSTRACT: Immune studies were performed in eight pregnancies occurring after renal transplantation (tx). In three cases a regular, long-term immune monitoring before, during, and after the pregnancy was possible. The results showed 1) no changes concerning OKT 3, 4, 8, and SMIg-defined T- and B-lymphocyte subsets in the mothers: 2) a higher level of spontaneous E- and normal E-rosette-defined T-subsets in the mothers rejecting their allografts; 3) a stronger response to mitogen and antigen stimulation and a stronger mixed lymphocyte culture (MLC) response towards the infants also in those rejecting their grafts; 4) the offspring of the transplanted mothers showed a weaker immune responder state compared with the offspring of six age-matched normal mothers.

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