• Immunoreproduction;
  • female fertility regulation;
  • adjuvants;
  • immunity

ABSTRACT: Corynebacterium parvum was compared with Freund's complete adjuvant (FCA) for potentiation of the rabbit immune response to β-human chorionic gonadotropin linked to tetanus toxoid (β-hCG-TT). With each adjuvant, antibodies to hCG were detected using passive hemagglutination. Higher antibody titers were produced by FCA-treated animals. The ability of antisera to β-hCG-TT to neutralize the biological action of native hCG was determined by the rat uterine weight assay. Anti-β-hCG-TT sera from C. parvum-treated rabbits were not significantly different (p > 0.10) from FCA potentiated anti-β-hCG-TT sera in neutralizing hCG-induced uterine weight gain. C. parvum has potential for future application in active immunization studies of fertility regulation.