Immunohistochemical Findings in Acute Atherosis Associated With Intrauterine Growth Retardation

Authors

  • Caelos Labarrere MD,

    Research Fellow of CONICET, Corresponding author
    1. Departments of Pathology and Obstetrics, Hospital Italiano, Buenos Aires, Argentina
    2. Department of Pathology, Sanatorio Guemes, Buenos Aires, Argentina
    3. CINEOT (Fundación Ottolenghi and CONICET), Buenos Aires, Argentina
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  • José Alonso,

    1. Departments of Pathology and Obstetrics, Hospital Italiano, Buenos Aires, Argentina
    2. Department of Pathology, Sanatorio Guemes, Buenos Aires, Argentina
    3. CINEOT (Fundación Ottolenghi and CONICET), Buenos Aires, Argentina
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  • Jorge Manni,

    1. Departments of Pathology and Obstetrics, Hospital Italiano, Buenos Aires, Argentina
    2. Department of Pathology, Sanatorio Guemes, Buenos Aires, Argentina
    3. CINEOT (Fundación Ottolenghi and CONICET), Buenos Aires, Argentina
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  • Enzo Domenichini,

    1. Departments of Pathology and Obstetrics, Hospital Italiano, Buenos Aires, Argentina
    2. Department of Pathology, Sanatorio Guemes, Buenos Aires, Argentina
    3. CINEOT (Fundación Ottolenghi and CONICET), Buenos Aires, Argentina
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  • Omar Althabe

    1. Departments of Pathology and Obstetrics, Hospital Italiano, Buenos Aires, Argentina
    2. Department of Pathology, Sanatorio Guemes, Buenos Aires, Argentina
    3. CINEOT (Fundación Ottolenghi and CONICET), Buenos Aires, Argentina
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Department of Pathology, Hospital Italiano, Gascón 450, 1181-Buenos Aires, Argentina.

Abstract

ABSTRACT: Lesions of acute atherosis in 23 placentas from pregnancies complicated by fetal growth retardation (less than tenth percentile) were studied by an immunoperoxidase staining. Twelve of them were from normotensive pregnancies, ten complicated by pregnancy induced hypertension, and the remaining associated with systemic lupus erythematosus. Twentythree placentas with physiological changes of the spiral arteries corresponding to normal pregnancies served as controls. Six of the cases complicated by fetal growth retardation showed absence of physiological changes in basal decidua. Massive intramural granular deposits of IgM, a smaller amount of C3 and C1q, and slight deposits of IgA and IgG were found in vessels with acute atherosis. No intramural deposition of immunoglobulins or complement was observed in vessels with or without physiological changes. The presence of granular deposits of immunoglobulins and complement within the vessel walls with acute atherosis may be related to an immunological disorder, probably mediated by immune complexes.

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