Clindamycin Levels in Reproductive Tissues

Authors

  • SUSAN R. JOHNSON MD,

    Corresponding author
    1. Department of Obstetrics and Gynecology, The University of Iowa College of Medicine, Iowa City, Iowa
      Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, lA 52242.
    Search for more papers by this author
  • C. ROSEMARIE PETZOLD,

    1. Department of Obstetrics and Gynecology, The University of Iowa College of Medicine, Iowa City, Iowa
    Search for more papers by this author
  • RUDOLPH P. GALASK

    1. Department of Obstetrics and Gynecology, The University of Iowa College of Medicine, Iowa City, Iowa
    Search for more papers by this author

Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, lA 52242.

Abstract

ABSTRACT: Clindamycin is widely used in a variety of obstetric and gynecologic infections. Despite in vitro and clinical evidence of activity against anaerobes, genital organ tissue levels resulting from intravenous administration of the drug have not previously been reported. Following a single intravenous infusion of 600 mg of clindamycin phosphate, tissue levels were determined in operative specimens obtained from ten women. Specimens of cervix, uterus, fallopian tube, and ovary were obtained, and mean Clindamycin levels for each site were: cervix, 2,63 μg/ml; endometrium, 5.58 μg/ml; myometrium, 2.39 μg/ml; fallopian tube, 2.96 μg/ml; and ovary, 3.74 μg/ml. The mean serum level was 6.26 μg/ml at the time of uterine artery interruption. The clindamycin concentrations at all sites exceeded the usual therapeutic minimal inhibitory concentration, substantiating the usefulness of clindamycin in obstetric and gynecologic anaerobic infections.

Ancillary