Primary Chronic Abortion, Preeclampsia, Idiopathic Intrauterine Growth Retardation, Hydatidiform Mole, and Choriocarcinoma: A Unifying Concept


Department of Pathology, Hospital Italiano, Gascon 450, 1181 Buenos Aires, Argentina.


ABSTRACT: Different degrees of maternal hyporesponse, as far as blocking activity is concerned, are proposed for primary chronic abortion, preeclampsia, and idiopathic intrauterine growth retardation. On the other hand, a maternal hyperresponse to fetal antigens with a higher production of blocking antibodies may be related to an unusual proliferation of the trophoblast in cases of hydatidiform mole and choriocarcinoma.