Histopathologic Alterations in the Decidua in Human Spontaneous Abortion: Loss of Cells With Large Cytoplasmic Granules

Authors

  • DAVID A. CLARK,

    Corresponding author
    1. Departments of Medicine, Obstetrics, and Gynecology, Host Resistance and Reproductive Biology Programs, McMaster University, Hamilton, Ontario, Canada
      Department of Medicine, Obstetrics, and Gynecology, Host Resistance and Reproductive Biology Programs, Mc-Master University, 1200 Main Street West Room 3V39, Hamilton, Ontario L8N 325, Canada.
    Search for more papers by this author
  • JAMES MOWBRAY,

    1. Department of Experimental Pathology, St. Mary's Hospital Medical School, London, England
    Search for more papers by this author
  • JENNIFER UNDERWOOD,

    1. Department of Experimental Pathology, St. Mary's Hospital Medical School, London, England
    Search for more papers by this author
  • HILLARY LIDELL

    1. Department of Obstetrics and Gynecology, St. Mary's Hospital Medical School, London, England
    Search for more papers by this author

Department of Medicine, Obstetrics, and Gynecology, Host Resistance and Reproductive Biology Programs, Mc-Master University, 1200 Main Street West Room 3V39, Hamilton, Ontario L8N 325, Canada.

Abstract

ABSTRACT: The histopathology of decidua obtained from the placental bed was evaluated by phloxine-tartrazine staining, which allows clear definition of cells with cytoplasmic granules. Mononuclear cells with large granules were seen in biopsy specimens taken from women at 8–31 weeks of normal pregnancy. In contrast, cells with large granules were missing in sections taken from the decidua of five women who were aborting or were destined to abort. Since the presence of suppressor cell activity in murine decidua correlates with the success of pregnancy and since this suppression is associated with small lymphocytes with cytoplasmic granules, the observations made using human placental bed biopsy material suggest that a possible suppressor cell deficiency might occur in the early stages of spontaneous abortion in human females.

Ancillary