Cell-Mediated Immunity in Infertility

Authors

  • Dr. DEBORAH J. ANDERSON,

    Corresponding author
    1. Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston
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  • JOSEPH A. HILL

    1. Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston
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Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, 250 Longwood Ave. Rm. 204, Boston, MA 02115.

Abstract

ABSTRACT: A role of cell-mediated immunity in immunologic infertility is indicated by a number of animal immunization studies and by reported clinical associations between cellular immune responses and infertility. Furthermore, recent technical advances in the field of cellular immunology have enabled advanced studies on the cellular and soluble mediators of cell-mediated immune responses and their interactions with reproductive processes. In this article we review some of the recent technical and conceptual advances in cellular immunology, the classic literature on cellular immune responses in infertility, and recent evidence that certain products of activated lymphocytes and macrophages significantly affect reproductive functions.

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