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Keywords:

  • CBA/J ×DBA/2 abortion system;
  • spleen cells;
  • anti-abortive effect

ABSTRACT: An anti-abortive effect of a progesterone-induced blocking factor has been shown in the CBA/J × DBA/2 abortion system. I.p. injections of pregnant mice on days 7.5, 9.5, and 11.5 of gestation with dialyzed supernatants from progesterone-treated murine pregnancy spleen cells (but not from control ones) significantly (P< 0.01) reduced the resorption rate from 47.7% in the untreated animals to 20.7%.