Laboratoire d'Histologie-Embryologie et Cytogénétique, CNHS UA 561, Faculté de Médecine, Besançon, France.
Human Seminal Plasma Suppresses the Chemiluminescence of Polymorphonuclears Without Modifying Phagocytosis
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 23, Issue 2, pages 64–68, June 1990
How to Cite
BOUVET, J.-P., D'AZAMBUJA, S., ROUX, C., LEBRUN, L. and PILLOT, J. (1990), Human Seminal Plasma Suppresses the Chemiluminescence of Polymorphonuclears Without Modifying Phagocytosis. American Journal of Reproductive Immunology, 23: 64–68. doi: 10.1111/j.1600-0897.1990.tb00673.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted April 18, 1990
- seminal plasma;
- oxygen radicals;
ABSTRACT: The suppressive activity of human seminal plasma was confirmed on the luminol-amplified chemiluminescent reaction of human polymorphonuclears. This suppression was found to be dose-dependent and noncytotoxic. The responsible factor appeared to be a radical scavenger of low molecular weight, acting selectively on hydrogen peroxide. Correlation with glandular markers of semen indicated this molecule to have a prostatic origin. Neither crude seminal plasma nor this factor were found to suppress intracellular engulfment and killing of bacteria. This molecule seems to cooperate with the other semen antioxidants to protect sperm cells from extracellular oxygen radicals.