Immunosuppressive Factor in Cow Follicular Fluid
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 26, Issue 4, pages 173–177, December 1991
How to Cite
VESELSKÝ, L., DOSTÁL, J., LANDA, V., STANĚK, R. and VINTER, P. (1991), Immunosuppressive Factor in Cow Follicular Fluid. American Journal of Reproductive Immunology, 26: 173–177. doi: 10.1111/j.1600-0897.1991.tb00719.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted November 19, 1991
- cow follicular fluid proteinase inhibitor;
- embryo development
ABSTRACT: The activity of the immunosuppressive fraction and proteinase inhibitor isolated from cow follicular fluid was investigated. The immunosuppressive factor was separated from the accompanying proteinase inhibitor by Sepharose 6B and Sephacryl S-200 column chromatography.
In vitro, the fraction significantly reduced mitogen-induced lymphocyte proliferation. In vivo, the fraction inhibited mouse plaque formation. However, the factor had no effect on the development of intact or zona free embryos. The active components have a molecular mass of about 110,000.