Peritoneal Fluid lnterleukin-1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease


Address reprint requests to Dr. Hidehiro Mori, Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasamachi, Gifu 500, Japan.


ABSTRACT: The levels of interleukin 1β (IL-1β) and tumor necrosis factor (TNF) in peritoneal fluid (PF-IL-1β and PF-TNF) and production of IL-1β and TNF by peritoneal macrophages were determined in patients with benign gynecologic disease. The level of PF-IL-1β was elevated in the acute pelvic inflammatory disease (PID) and stages I and II endometriosis (E I/II) groups compared with the normal pelvis group, but not in the myoma of the uterus, ovarian cyst, and postinflammatory pelvic adhesion groups. The level of PF-TNF was elevated in the PID, EI/II and stages III and IV endometriosis (EIII/IV) groups. There was no correlation between the levels of PF-IL-β and PF-TNF. Neither the level of PF-IL-β nor that of PF-TNF was correlated with the concentration of peritoneal macrophages. Peritoneal macrophages produced IL-1β and TNF in vitro in the absence of stimulants. The levels of PF-IL-1β and PF-TNF are presumably linked to the activation of peritoneal macrophages.