Long-Term Follow-up of Children Born to Women Immunized With Tetanus Toxoid During Pregnancy

Authors

  • THOMAS J. GILL III,

    Corresponding author
    1. Departments of Pathology and Pediatrics, University of Pittsburgh School of Medicine, and General Clinical Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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  • RAYMOND B. KARASIC,

    1. Departments of Pathology and Pediatrics, University of Pittsburgh School of Medicine, and General Clinical Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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  • JANET ANTONCIC,

    1. Departments of Pathology and Pediatrics, University of Pittsburgh School of Medicine, and General Clinical Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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  • BRUCE S. RABIN

    1. Departments of Pathology and Pediatrics, University of Pittsburgh School of Medicine, and General Clinical Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261.

Abstract

ABSTRACT: Ten years after transplacental immunization with tetanus toxoid, the antibody responses of the immunized children to a booster immunization with 5 Lf tetanus toxoid did not differ from those of the control children. The tetanus toxoid-stimulated lymphocyte proliferative responses showed that there was no tolerance to tetanus toxoid induced by transplacental immunization, and the stimulation indices suggested that there may be some long-term memory for tetanus toxoid among the T lymphocytes in children who had been transplacentally immunized by maternal immunization with a standard dose of tetanus toxoid.

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