Trophoblast Immunity in Human Pregnancy Defined by Antiidiotype

Authors

  • DONALD S. TORRY,

    1. Department of Pathology, Harvard Medical School and Laboratory of Molecular Carcinogenesis, Dana Farber Cancer Institute, Boston, Massachusetts
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  • W. PAGE FAULK,

    1. Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Methodist Hospital, Indianapolis, Indiana
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  • Dr. JOHN A. MCINTYRE

    Corresponding author
    1. Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Methodist Hospital, Indianapolis, Indiana
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Methodist Center for Reproduction and Transplantation Immunology, 1701 N. Senate Blvd., Indianapolis, IN 46202.

Abstract

ABSTRACT: Successful reproduction in mammals requires the mother to immunologically accept genetically disparate tissues. Allotypic trophoblast antigens (TLX) are thought to be responsible for influencing maternal acceptance of the feto-placental graft, and faulty regulation of immunity to TLX antigens has been associated with recurrent pregnancy losses. In this report, rabbit antiidiotype (RAb2) was produced to a human TLX antibody (Ab1). This RAb2 detected TLX cross-reactive idio-types (CRI) on antitrophoblast IgG from women with normal and abnormal pregnancies. These findings support an hypothesis that women respond immunologically to allotypic trophoblast antigens, and that idiotype-antiidiotype regulation of this response is characteristic of normal pregnancy.

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