Effect of Labor on Lymphocyte Subsets in Full-Term Neonates
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 28, Issue 2, pages 71–73, September 1992
How to Cite
SAMELSON, R., LARKEY, D. M., AMANKWAH, K.S. and MCCONNACHIE, P. (1992), Effect of Labor on Lymphocyte Subsets in Full-Term Neonates. American Journal of Reproductive Immunology, 28: 71–73. doi: 10.1111/j.1600-0897.1992.tb00761.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted July 20, 1992
- Lymphocyte subsets;
- fetal immunology;
- lymphocyte ontogeny
PROBLEM: To determine the effect of labor on lymphocyte subsets in full-term neonates. Method of Study. Cord blood obtained at delivery from full-term neonates, six born vaginally and six born by elective Cesarean section, was analyzed for lymphocyte subsets. Monoclonal antibodies, immunofluorescence, and flow cytometry were utilized to determine the lymphocyte phenotype frequencies in these neonates. These frequencies were compared by mode of delivery and to adult peripheral blood reference ranges using a two-tailed Student's t-test,P<0.05.
RESULTS: A profile of significantly elevated T (CD2, CD3) and helper cells (CD4) and depressed Natural Killer cells (CD16, CD56) is characteristic of term Cesarean section neonates. Significantly depressed frequency of T cells (CD2, CD3) and helper T cells (CD4) and elevated Natural Killer cells (CD16, CD56) is characteristic of vaginally delivered neonates
CONCLUSIONS: The mode of delivery affects the lymphocyte subset frequencies in full-term neonates.