The Hopkins Lupus Pregnancy Center: 1987–1991 Update

Authors

  • MICHELLE PETRI,

    Corresponding author
    1. Division of Molecular and Clinical Rheumatology, Department of Medicine, Baltimore, Maryland
    2. Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • DENISE HOWARD,

    1. Division of Molecular and Clinical Rheumatology, Department of Medicine, Baltimore, Maryland
    2. Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • JOHN REPKE,

    1. Department of Obstetrics and Gynecology, Baltimore, Maryland
    2. Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • DANIEL W. GOLDMAN

    1. Division of Molecular and Clinical Rheumatology, Department of Medicine, Baltimore, Maryland
    2. Johns Hopkins University School of Medicine, Baltimore, Maryland
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Address correspondence to Dr. Petri, 1830 E. Monument Street, Suite 7500, Baltimore, MD 21205.

Abstract

ABSTRACT: The course of pregnancy in patients with systemic lupus erythematosus is not known. The Hopkins Lupus Pregnancy Center has followed 64 patients (74 pregnancies) prospectively since 1987. Patients are seen monthly and clinical and pregnancy-related data collected, with particular emphasis on the occurrence of lupus flare. Flare rate during pregnancy was 1.63 per person-year, compared to 0.64-0.65 after delivery or in non-pregnant patients. Flare did not influence pregnancy outcome. Low serum C3 or C4 and high anticardiolipin antibody predicted pregnancy loss, and prednisone dose, aspirin use, diastolic second trimester blood pressure, C3 at first visit, and race predicted preterm birth. Maternal flare and preterm birth are important risks in lupus pregnancy. The latter can be predicted from maternal pregnancy data.

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