Maternal-Fetal Histocompatibility in Intrauterine Growth Retarded and Normal Weight Babies

Authors

  • MARION S. VERP M.D.,

    Corresponding author
    1. Department of Obstetrics and Gynecology, The Pritzker School of Medicine. The University of Chicago, Chicago, Illinois.
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  • MARK SIBUL,

    1. Department of Obstetrics and Gynecology, The Pritzker School of Medicine. The University of Chicago, Chicago, Illinois.
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  • CHRIS BILLSTRAND,

    1. Department of Obstetrics and Gynecology, The Pritzker School of Medicine. The University of Chicago, Chicago, Illinois.
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  • GARY BELEN,

    1. Department of Obstetrics and Gynecology, The Pritzker School of Medicine. The University of Chicago, Chicago, Illinois.
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    • Gary Belen is now at the Boston University School of Medicine, Boston, Massachusetts. Michael Hsu is now at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Presented at the 39th Annual Meeting of the Society of Gynecologic Investigation, San Antonio, March 18–21, 1992.

  • MICHAEL HSU,

    1. Department of Obstetrics and Gynecology, The Pritzker School of Medicine. The University of Chicago, Chicago, Illinois.
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  • CAROLE OBER

    1. Department of Obstetrics and Gynecology, The Pritzker School of Medicine. The University of Chicago, Chicago, Illinois.
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Department of Obstetrics and Gynecology, MC2050, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637.

Abstract

PROBLEM: To determine whether risk for intrauterine growth retardation (IUGR) is increased in HLA-DQA1 compatible pregnancies.

METHOD: Paired maternal and cord blood samples were obtained from 30 IUGR and 31 non-IUGR pregnancies delivered at a university hospital. Samples were typed for eight HLA-DQA1 alleles using 10 sequence-specific oligonucleotide probes. Associations between IUGR and HLA-DQ compatibility status, and other risk factors were examined using logistic regression analysis.

RESULTS: HLA-DQ compatibility and history of spontaneous abortion were not individually significant risk factors for IUGR; however, there was an interactive effect between these two factors and IUGR (P = 0.085) that improved the overall fit of the logistic model (P < 0.001). No individual allele was more common in IUGR pregnancies.

CONCLUSION: HLA compatibility per se is not associated with sufficient inhibition of fetal growth to result in IUGR as defined. However, in women with a history of spontaneous abortion, HLA compatibility may have an effect.

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