T-Cell Receptors Are Expressed but Down-Regulated on Intradecidual T Lymphocytes


Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara-shi, Nara 634, Japan.


PROBLEM: Dietl et al. considered “intradecidual T cell tolerance towards fetal antigens” with their observation that intradecidual T cells lack immunohistochemically detectable amounts of T cell receptor (TCR) molecules while expressing normal amounts of CD3 molecules during early normal pregnancy.

METHOD: To reevaluate these findings we examined the TCR and CD3 expression on intradecidual T cells using flow cytometry.

CONCLUSIONS: In our study, all intradecidual CD3+ T cells expressed either TCR αβ or TCR γδ. However, the expression of the CD3/TCR complex on intradecidual T cells was down-regulated. The level of CD3/TCR complex expression on intradecidual T cells was about two-thirds of that on peripheralblood T cells. Further, the proportions of αβ + and γδ + cells in CD3 + cells did not significantly differ between decidua and peripheral blood.