Cytokines in Semen of Normal Men and of Patients With Andrological Diseases
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 31, Issue 2-3, pages 99–103, March-April 1994
How to Cite
Comhaire, F., Bosmans, E., Ombelet, W., Punjabi, U. and Schoonjans, F. (1994), Cytokines in Semen of Normal Men and of Patients With Andrological Diseases. American Journal of Reproductive Immunology, 31: 99–103. doi: 10.1111/j.1600-0897.1994.tb00853.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Accepted January 31, 1994
- Interleukin 6;
- interleukin 1β;
- human reproduction;
- male infertility;
- immunological infertility
PROBLEM: The potential value of assessment of cytokine concentrations for the diagnosis of certain pathological conditions of male reproduction has not been fully evaluated.
METHOD: The concentrations of interleukin 6 (IL-6, pg/mL), its soluble receptor (IL-6 sR, ng/mL), and of interleukin 1β (IL-1β, pg/mL) have been measured in semen samples of 114 men and 12 corresponding blood sera.
RESULTS: The concentration of IL-6 was unrelated to that of its receptor. Both IL-6 and IL-6 sR were higher in the first (mean: 69 and 31 resp.) than in the second fraction (39 and 13) of split ejaculates, and were within normal limits in vasectomised men. The Interleukin Iβ concentration presented a strong positive correlated with that of IL-6 (r=0.74, P<0.001). The concentrations of IL-6 and IL-1β were unrelated to sperm concentration, motility and morphology, and they were within normal limits in immunological cases. Both IL-6 and IL-1β were higher (P<0.01) in cases with accessory gland inflammation.
CONCLUSIONS: Measurement of in particular IL-6 in semen may contribute to the diagnosis of inflammatory disease of the accessory sex glands (positive predictive value = 98%, sensitivity = 72%, specificity = 94%), but it is not relevant for the diagnosis of immunological disease.