This work is dedicated to our friend and colleague Olaf Heine, MD, who died on December 5, 1993.
Diagnostic and Prognostic Significance of Anticardiolipin Antibodies in Patients With Recurrent Spontaneous Abortions
Version of Record online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 33, Issue 3, pages 228–233, March 1995
How to Cite
MELK, A., MUELLER-ECKHARDT, G., POLTEN, B., LATTERMANN, A., HEINE, O. and HOFFMANN, O. (1995), Diagnostic and Prognostic Significance of Anticardiolipin Antibodies in Patients With Recurrent Spontaneous Abortions. American Journal of Reproductive Immunology, 33: 228–233. doi: 10.1111/j.1600-0897.1995.tb00889.x
- Issue online: 9 MAY 2013
- Version of Record online: 9 MAY 2013
- Accepted August 22, 1994
- Anticardiolipin antibodies;
- recurrent spontaneous abortion (RSA)
PROBLEM: The role of ACA in unexplained RSA is controversial. In the present study, diagnostic and prognostic aspects were investigated.
METHOD: One hundred five nonpregnant patients with primary, 29 with secondary RSA, and 209 controls were investigated for IgG-ACA. Follow-up studies were done during pregnancy in 76 individuals. IgM-ACA were tested in a subset of patients.
RESULTS: Elevated ACA levels were significantly more frequent in both patient groups (26 and 24%) than in controls (16%). However, there was no correlation of ACA with various parameters including pregnancy outcome. In ACA-positive patients with successful pregnancy a significant decrease of ACA values during pregnancy was observed, while ACA remained high in aborting patients. IgG- and IgM-ACA correlated well.
CONCLUSIONS: Although the data from nonpregnant RSA patients does not allow diagnostic or prognostic conclusions to be drawn, sequential testing of ACA-positive individuals provides the possibility to foresee pregnancy outcome.