Sequential Measurements of Human Decidua-Associated Protein (hDP) 200 in the Uterine Fluid During the Menstrual Cycle

Authors

  • Reuvit Halperin M.D., Ph.D.,

    Corresponding author
    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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  • Arie Herman,

    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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  • Abraham Golan,

    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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  • Eran Hadas,

    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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  • David Schneider,

    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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  • Ian Bukovsky,

    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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  • Raphael Ron-El

    1. Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel
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Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin 70300, Israel.

Abstract

PROBLEM: To examine the relationship between the concentration of uterine fluid human decidua-associated protein (hDP) 200, identified as a monoclonal rheumatoid factor, and different phases of the menstrual cycle.

METHODS: Sequential measurements of hDP 200 concentration in uterine fluid were performed in 11 normal ovulatory women, aged 22–36 years. The samples were collected in early proliferative phase, late proliferative phase, periovulatory period, early secretory phase, and late secretory phase.

RESULTS: Consistent fluctuations of hDP 200 levels in uterine fluid were found throughout the menstrual cycle. High levels were found during early proliferative phase and periovulatory period related to significantly lower levels during late proliferative and early luteal phases.

CONCLUSION: There is menstrual phase dependent variation in the uterine fluid levels of hDP 200.

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