Antiphospholipid Antibodies in Patients With Preeclampsia
Version of Record online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 36, Issue 2, pages 81–85, August 1996
How to Cite
Allen, J. Y., Tapia-Santiago, C. and Kutteh, W. H. (1996), Antiphospholipid Antibodies in Patients With Preeclampsia. American Journal of Reproductive Immunology, 36: 81–85. doi: 10.1111/j.1600-0897.1996.tb00143.x
- Issue online: 6 SEP 2011
- Version of Record online: 6 SEP 2011
- Accepted November 29, 1995
- Anticardiolipin antibodies;
- antiphospholipid antibodies;
PROBLEM: To determine the incidence of anticardiolipin and antiphosphatidylserine antibodies in women with preeclampsia.
METHODS: Sera from 100 women with preeclampsia and 100 normotensive pregnant women in the third trimester were assayed for anticardiolipin and antiphosphatidylserine antibodies.
RESULTS: Antiphosphatidylserine antibodies were positive for IgM in 1 patient (1%) and for IgG in 4 patients (4%). IgM antibodies to cardiolipin were positive in two patients (2%) while IgG antibodies to cardiolipin were positive in nine patients (9%). Only 3% of the control women were positive for antiphospholipid antibodies. None of the patients or controls had positive levels of IgA anticardiolipin or antiphosphatidylserine antibodies.
CONCLUSIONS: Elevated levels of IgG or IgM antibodies to cardiolipin and phosphatidylserine were detected in 11/100 (11%) of women diagnosed with preeclampsia in the third trimester compared to only 3/100 (3%) positive in controls (P < 0.05). These findings suggest that antiphospholipid antibodies may play a pathogenic role in some women with preeclampsia.