Quantitative Assessment of Cytokines (GROα and IL-10) in Human Seminal Plasma During Genitourinary Inflammation
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 36, Issue 2, pages 90–95, August 1996
How to Cite
Rajasekaran, M., Hellstrom, W. and Sikka, S. (1996), Quantitative Assessment of Cytokines (GROα and IL-10) in Human Seminal Plasma During Genitourinary Inflammation. American Journal of Reproductive Immunology, 36: 90–95. doi: 10.1111/j.1600-0897.1996.tb00145.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted November 3, 1995
- Granulocyte elastase;
- sperm function
PROBLEM: Mechanisms involved in infertility due to genitourinary (GU) inflammation are unknown. The production of pro-inflammatory (GROα) and anti-inflammatory (IL-10) cytokines in seminal plasma is monitored in this study.
METHOD: GROα, IL-10, and granulocyte elastase were evaluated in semen from I) normal, II) infertile patients, and III) infertile patients with leukocytospermia.
RESULTS: GROα in infertile patients with GU inflammation was 1.5-fold higher compared to group II and 2.5-fold higher compared to group I patients. The IL-10 levels were 12- to 16-fold lower compared to GROα in these samples. Mean ratio of GROα to IL-10 was higher in group III than the other two groups. A positive correlation was observed between granulocyte elastase and GROα in all groups. Group III patients exhibited poor sperm parameters.
CONCLUSIONS: A shift towards increased production of pro-inflammatory chemokine GROα may have a potential role in male infertility associated with GU inflammation.