Anti-Seminal Plasma Antibodies Associated With Infertility: I. Serum Antibodies Against Normozoospermic Seminal Plasma in Patients With Unexplained Infertility
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 36, Issue 4, pages 198–203, October 1996
How to Cite
Fichorova, R.N. and Boulanov, I.D. (1996), Anti-Seminal Plasma Antibodies Associated With Infertility: I. Serum Antibodies Against Normozoospermic Seminal Plasma in Patients With Unexplained Infertility. American Journal of Reproductive Immunology, 36: 198–203. doi: 10.1111/j.1600-0897.1996.tb00163.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted August 10, 1995
- Enzyme-linked immunosorbent assay;
- human seminal plasma antigens;
- immunologic infertility;
- sperm agglutination
PROBLEM: To determine whether patients whose infertility remains unexplained (by routine physical and laboratory investigations including sperm antibody testing) exhibit significantly elevated humoral anti-seminal plasma immune responses in comparison to fertile individuals.
METHOD: Sera from 72 infertile couples were examined by ELISA for the presence of antibodies against normozoospermic seminal plasma (NSP). A group of 36 fertile individuals was used to determine the level of physiological reactivity. Kibrick's and Friberg's sperm-agglutination tests were employed to distinguish patients routinely diagnosed as immunologically infertile.
RESULTS: Anti-NSP reactivity was elevated in 18% of male and 26% of female patients. In the female patients, the prevalence rate for elevated anti-NSP reactivity was significantly higher among partners of positive men. In only 4% the positive anti-NSP results coincided with sperm-agglutinating antibodies.
CONCLUSION: NSP constituents other than sperm-coating antigens might interfere with infertility related autoimmune imbalance. The identification of the corresponding NSP antigens might help to resolve more cases of unexplained infertility.