Interleukin-10 in Preovulatory Follicular Fluid of Patients Undergoing In-Vitro Fertilization and Embryo Transfer

Authors

  • Eli Geva,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Joseph B. Lessing,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Liat Lerner-Geva,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Foad Azem,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Israel Yovel,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Dalit Ben-Yosef,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Uriel Barkai,

    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Search for more papers by this author
  • Dr. Ami Amit

    Corresponding author
    1. In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
      IVF Unit, Serlin Maternity Hospital, P.O. Box 7079, Tel Aviv, Israel.
    Search for more papers by this author

IVF Unit, Serlin Maternity Hospital, P.O. Box 7079, Tel Aviv, Israel.

Abstract

PROBLEM: The present study aimed at investigating the presence of Interleukin-10 (IL-10) in preovulatory follicular fluid (FF) and its possible correlation with 17-β-estradiol (E2) and progesterone (P) levels, and treatment outcome in patients undergoing in-vitro fertilization-embryo transfer (IVF-ET).

METHODS: Twenty consecutive patients with tubal factor infertility who underwent oocyte retrieval for IVF-ET were assayed for pooled, preovulatory FF levels of IL-10, E2, and P.

RESULTS: The mean FF levels of IL-10, E2, and P were 78.7 ± 104.7 pg/ml, 2,787.0 ± 726.1 pg/ml, and 1.5 ± 0.8 ng/ml, respectively. No correlation was found between preovulatory FF concentration of IL-10, E2, oocyte number, oocyte fertilization rate, embryo quality, and pregnancy rate. The levels of IL-10 were found to be negatively correlated with P concentration, although not significantly (P = 0.057).

CONCLUSION: Interleukin-10 exists in the preovulatory FF. Further investigations are needed to determine the role of IL-10 in the folliculogenesis.

Ancillary