Interleukin-10 in Preovulatory Follicular Fluid of Patients Undergoing In-Vitro Fertilization and Embryo Transfer
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 37, Issue 2, pages 187–190, February 1997
How to Cite
Geva, E., Lessing, J. B., Lerner-Geva, L., Azem, F., Yovel, I., Ben-Yosef, D., Barkai, U. and Amit, A. (1997), Interleukin-10 in Preovulatory Follicular Fluid of Patients Undergoing In-Vitro Fertilization and Embryo Transfer. American Journal of Reproductive Immunology, 37: 187–190. doi: 10.1111/j.1600-0897.1997.tb00211.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted August 5, 1996
- Follicular fluid;
PROBLEM: The present study aimed at investigating the presence of Interleukin-10 (IL-10) in preovulatory follicular fluid (FF) and its possible correlation with 17-β-estradiol (E2) and progesterone (P) levels, and treatment outcome in patients undergoing in-vitro fertilization-embryo transfer (IVF-ET).
METHODS: Twenty consecutive patients with tubal factor infertility who underwent oocyte retrieval for IVF-ET were assayed for pooled, preovulatory FF levels of IL-10, E2, and P.
RESULTS: The mean FF levels of IL-10, E2, and P were 78.7 ± 104.7 pg/ml, 2,787.0 ± 726.1 pg/ml, and 1.5 ± 0.8 ng/ml, respectively. No correlation was found between preovulatory FF concentration of IL-10, E2, oocyte number, oocyte fertilization rate, embryo quality, and pregnancy rate. The levels of IL-10 were found to be negatively correlated with P concentration, although not significantly (P = 0.057).
CONCLUSION: Interleukin-10 exists in the preovulatory FF. Further investigations are needed to determine the role of IL-10 in the folliculogenesis.