Expression of an Immunomodulatory Protein Known as Progesterone Induced Blocking Factor (PIBF) Does Not Correlate With First Trimester Spontaneous Abortions in Progesterone Supplemented Women
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 37, Issue 4, pages 330–334, April 1997
How to Cite
Check, J. H., Ostrzenski, A. and Klimek, R. (1997), Expression of an Immunomodulatory Protein Known as Progesterone Induced Blocking Factor (PIBF) Does Not Correlate With First Trimester Spontaneous Abortions in Progesterone Supplemented Women. American Journal of Reproductive Immunology, 37: 330–334. doi: 10.1111/j.1600-0897.1997.tb00239.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted December 30, 1996
- Natural killer cells;
- progesterone receptors;
PROBLEM: An immunomodulatory protein known as the progesterone induced blocking factor (PIBF) has been found to positively correlate with early pregnancy beta human chorionic gonadotropin (B-hCG) levels. The study presented herein evaluated PIBF levels from conception to the end of the first trimester to determine if lower levels will correlate with first trimester spontaneous abortions (SAB).
METHOD: Progesterone induced blocking factor expression by lymphocytes measured using an immunocytochemistry method was compared in pregnant women with ongoing vs. failed pregnancies.
RESULTS: There were no differences in the proportion of women having lymphocytes expressing PIBF or in the median numbers when comparing ongoing vs. failed pregnancies. There was no B-hCG interval where failed pregnancies were found to have lower frequency of PIBF expressing lymphocytes.
CONCLUSION: Inadequate PIBF expression independent of low P levels does not appear to be an etiologic factor for first trimester SABs; thus measuring this protein in pregnant women lacks practical usefulness.