Maternal Anti-Placental Cell-Mediated Reactivity and Spontaneous Abortions

Authors

  • Raj Raghupathy

    Corresponding author
    1. Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
      Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
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Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait

Abstract

PROBLEM: Does Th1/Th2 balance determine pregnancy outcome, and if so, what determines Th1/Th2 balance in pregnancy?

METHOD: Review and synthesis of existing data.

RESULTS: A bias toward Th1 is strongly correlated with pregnancy failure in mice and humans. Pregnancy usually shifts the balance toward Th2 and placental factors/progesterone and progesterone-stimulated CD8+ T cell production of suppressor factor; TGFβ2 and IL4/ 10 may be responsible. The bias toward a Th1 response may result from intracellular parasitic infection and other as yet undefined factors.

CONCLUSION: The Th1/Th2 balance thesis appears to be valid.

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