Pathogenetic Implication of Interleukin-2 Expressed in Preeclamptic Decidual Tissues: A Possible Mechanism of Deranged Vasculature of the Placenta Associated with Preeclampsia
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 38, Issue 2, pages 83–88, August 1997
How to Cite
Hamai, Y., Fujii, T., Yamashita, T., Kozuma, S., Okai, T. and Taketani, Y. (1997), Pathogenetic Implication of Interleukin-2 Expressed in Preeclamptic Decidual Tissues: A Possible Mechanism of Deranged Vasculature of the Placenta Associated with Preeclampsia. American Journal of Reproductive Immunology, 38: 83–88. doi: 10.1111/j.1600-0897.1997.tb00280.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted April 30, 1997
- endothelial cell;
- lymphokine-activated killer cell;
PROBLEM: The purpose of this study is to clarify whether IL-2 expressed in the decidua in preeclampsia affects the angiogenesis of the placenta.
METHOD OF STUDY: We investigated the angiogenic substances released from human trophoblasts obtained from early pregnancy that had been pretreated with either IL-2, non-activated lymphocytes from peripheral blood mononuclear cells (PBMCs), decidual lymphocytes, or these lymphocytes activated by lymphokine (LAK cells). Angiogenic activity was determined by evaluating the ability of growth-promotion of cultured human microvascular endothelial cells (HMvECs) using MTT assay.
RESULTS: Trophoblasts pretreated with IL-2 or non-activated lymphocytes, irrespective of their origin, released angiogenic factor similar to those without pretreatment. However, trophoblasts pretreated with LAK cells released less angiogenic factor compared with those without pretreatment.
CONCLUSIONS: Interleukin-2 (IL-2) expressed in preeclamptic decidua might reduce the angiogenic substances arising from trophoblasts by inducing LAK cells from decidual lymphocytes, which might be relevant to deranged vasculature of the placenta, a characteristic histology in preeclampsia.