Evidence for an Elevation in Serum Interleukin-2 and Tumor Necrosis Factor-α Levels Before the Clinical Manifestations of Preeclampsia
Version of Record online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 38, Issue 2, pages 89–93, August 1997
How to Cite
Hamai, Y., Fujii, T., Yamashita, T., Nishina, H., Kozuma, S., Mikami, Y. and Taketani, Y. (1997), Evidence for an Elevation in Serum Interleukin-2 and Tumor Necrosis Factor-α Levels Before the Clinical Manifestations of Preeclampsia. American Journal of Reproductive Immunology, 38: 89–93. doi: 10.1111/j.1600-0897.1997.tb00281.x
- Issue online: 6 SEP 2011
- Version of Record online: 6 SEP 2011
- Accepted April 30, 1997
- Early pregnancy;
- immune regulation;
- tumor necrosis factor-α
PROBLEM: The purpose of this study is to clarify whether the disruption of immune regulation occurs in early pregnancy before the clinical manifestations of preeclampsia.
METHOD OF STUDY: The serum concentrations of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) were determined by using enzyme-linked immunoadsorbent assay (ELISA) in the first trimester of pregnancy in women who had preeclampsia develop after 28 weeks of pregnancy (preeclamptic group) and in women who completed pregnancy uneventfully (control group).
RESULTS: Serum concentrations of both IL-2 and TNF-α in the first trimester of the preeclamptic group were significantly higher than those of the control group.
CONCLUSIONS: That the perturbation of feto-maternal immune regulation may precede the clinical manifestations of preeclampsia, which may be of relevance in the development of preeclampsia, is suggested.