High Levels of Anticardiolipin Antibodies in Patients with Abnormal Embryo Morphology Who Attended an In Vitro Fertilization Program
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 39, Issue 3, pages 161–163, March 1998
How to Cite
Azem, F., Geva, E., Amit, A., Lerner-Geva, L., Shwartz, T., Ben-Yosef, D., Yovel, I. and Lessing, J. B. (1998), High Levels of Anticardiolipin Antibodies in Patients with Abnormal Embryo Morphology Who Attended an In Vitro Fertilization Program. American Journal of Reproductive Immunology, 39: 161–163. doi: 10.1111/j.1600-0897.1998.tb00349.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted September 25, 1997
- embryo quality;
- reproduction failure
PROBLEM: Recently, it has been suggested that anticardiolipin antibodies (ACAs) may serve as possible markers for reproductive failure. The association between ACAs and embryo morphology in patients undergoing in vitro fertilization (IVF) was investigated.
METHOD OF STUDY: This prospective study comprised 117 patients with either tubal factor or unexplained infertility. Embryo morphology was blindly scored from I to IV according to blastomere regularity and the presence of fragments. Anticardiolipin antibodies (immunoglobulin [Ig] G and IgM) were detected.
RESULTS: Anticardiolipin antibodies were found in 26 (50%) of the 52 patients with abnormal morphology, compared with 13 (20%) of the 65 patients with normal embryo morphology (P = 0.001). No statistically significant differences were found between the prevalence of ACAs among patients with tubal factor and those with unexplained infertility (29.6% and 36.5%, respectively).
CONCLUSIONS: Our study shows an association between embryo morphology and the presence of ACAs. This association may explain the low implantation rate and early pregnancy loss in patients with ACAs.