High Levels of Anticardiolipin Antibodies in Patients with Abnormal Embryo Morphology Who Attended an In Vitro Fertilization Program

Authors

  • Foad Azem,

    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Eli Geva,

    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Ami Amit,

    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Liat Lerner-Geva,

    1. Department of Clinical Epidemiology, The Chaim Sheba Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Tamar Shwartz,

    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Dalit Ben-Yosef,

    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Israel Yovel,

    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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  • Prof. Joseph B. Lessing

    Corresponding author
    1. Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
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Sara Racine IVF Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, 6 Weizman Street, Tel Aviv, 64239, Israel.

Abstract

PROBLEM: Recently, it has been suggested that anticardiolipin antibodies (ACAs) may serve as possible markers for reproductive failure. The association between ACAs and embryo morphology in patients undergoing in vitro fertilization (IVF) was investigated.

METHOD OF STUDY: This prospective study comprised 117 patients with either tubal factor or unexplained infertility. Embryo morphology was blindly scored from I to IV according to blastomere regularity and the presence of fragments. Anticardiolipin antibodies (immunoglobulin [Ig] G and IgM) were detected.

RESULTS: Anticardiolipin antibodies were found in 26 (50%) of the 52 patients with abnormal morphology, compared with 13 (20%) of the 65 patients with normal embryo morphology (P = 0.001). No statistically significant differences were found between the prevalence of ACAs among patients with tubal factor and those with unexplained infertility (29.6% and 36.5%, respectively).

CONCLUSIONS: Our study shows an association between embryo morphology and the presence of ACAs. This association may explain the low implantation rate and early pregnancy loss in patients with ACAs.

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