Secretion of Interleukin-2 from Unstimulated Peripheral Blood Mononuclear Cells Is a Possible Pathogenic Mechanism in Recurrent Abortion
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 40, Issue 1, pages 63–64, July 1998
How to Cite
HAMAI, Y., FUJII, T., KOZUMA, S., SHIBATA, Y. and TAKETANI, Y. (1998), Secretion of Interleukin-2 from Unstimulated Peripheral Blood Mononuclear Cells Is a Possible Pathogenic Mechanism in Recurrent Abortion. American Journal of Reproductive Immunology, 40: 63–64. doi: 10.1111/j.1600-0897.1998.tb00390.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted March 17, 1998
- Helper T cells;
- recurrent abortion
PROBLEM: The objective of this study was to evaluate the activated status of helper T cells in women with recurrent abortion.
METHOD OF STUDY: The spontaneous secretion of interleukin (IL)-2 from peripheral blood mononuclear cells (PBMCs) obtained from 12 women with primary partner-specific recurrent abortion and 7 normal females and 10 normal males was measured.
RESULTS: IL-2 concentrations in medium conditioned with PBMCs from the recurrent abortion group were 1.44 ± 0.32 (mean ± standard deviation) U/ml, whereas those from the normal female and male groups were below the minimum detectable concentration.
CONCLUSION: The fact that PBMCs from recurrent aborters spontaneously secrete IL-2 suggests that helper T cells are activated in recurrent aborters.