The Level of Human Decidua-Associated Protein (hDP) 200, Identified as a Monoclonal Rheumatoid Factor in the Fallopian Tube
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 41, Issue 4, pages 253–256, April 1999
How to Cite
Halperin, Dr. R., Hadas, E., Bukovsky, I. and Schneider, D. (1999), The Level of Human Decidua-Associated Protein (hDP) 200, Identified as a Monoclonal Rheumatoid Factor in the Fallopian Tube. American Journal of Reproductive Immunology, 41: 253–256. doi: 10.1111/j.1600-0897.1999.tb00435.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- Accepted August 12, 1998
- ectopic pregnancy;
- hDP 200;
- rheumatoid factor;
- tubal fluid;
- uterine fluid
PROBLEM: The aim of this study was to examine whether ectopic pregnancy is associated with increased levels of human decidua-associated protein (hDP) 200, identified as a monoclonal rheumatoid factor, in the related fallopian tube as compared with normal tubes.
METHOD OF STUDY: Tubal fluid samples were obtained prospectively from two groups of patients: group I, 20 patients admitted for total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH and BSO); group H, 14 women with ectopic pregnancy, undergoing unilateral salpingectomy by laparoscopy or laparotomy. hDP 200 was assayed using double-site enzyme-linked immunosorbent assay.
RESULTS: Very low levels of hDP 200 were found in normal tubes, while tubes with ectopic pregnancy demonstrated significantly higher levels of tubal fluid hDP 200 (P < 0.00001). In addition, in women with ectopic pregnancy, the uterine fluid level of hDP 200 was significantly lower than the level of hDP 200 in the tube containing ectopic pregnancy (P < 0.0001).
CONCLUSION: The increased level of hDP 200 (a monoclonal rheumatoid factor) in the tube containing ectopic pregnancy, as compared with uterine cavity and normal tubes, might be associated with the implantation site of the pregnancy.