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Pregnancy-Specific Glycoprotein Gene Expression in Recurrent Aborters: A Potential Correlation to Interleukin-10 Expression
Article first published online: 6 SEP 2011
American Journal of Reproductive Immunology
Volume 41, Issue 3, pages 174–182, March 1999
How to Cite
Arnold, L. L., Doherty, T. M., Flor, A. W., Simon, J. A., Chou, J. Y., Chan, W.-Y. and Mansfield, B. C. (1999), Pregnancy-Specific Glycoprotein Gene Expression in Recurrent Aborters: A Potential Correlation to Interleukin-10 Expression. American Journal of Reproductive Immunology, 41: 174–182. doi: 10.1111/j.1600-0897.1999.tb00530.x
- Issue published online: 6 SEP 2011
- Article first published online: 6 SEP 2011
- accepted June 18, 1998
- recurrent spontaneous abortion
PROBLEM: The expression of the pregnancy-specific glycoprotein (PSG) genes in the uterine endometrium of women experiencing recurrent first-trimester abortions, and potential correlations to cytokine expression were examined.
METHOD OF STUDY: Endometrial RNA, isolated from women with a history of either repetitive first-trimester pregnancy losses or uncomplicated pregnancies, was isolated and analyzed for PSG transcripts by the reverse transcriptase-polymerase chain reaction method. PSG genes showing different patterns of expression were expressed in baculovirus, and the purified proteins examined for their effects on cytokine expression.
RESULTS: The expression of PSG11 in the endometria of recurrent aborters was significantly lower than in that of controls (P < 0.01). When tested on monocytes, PSG11 stimulated secretion of interleukin (IL)-10.
CONCLUSIONS: The level of expression of the PSG11 gene in the uterine endometrium, during the peri-implantation period, correlates with the risk of pregnancy loss in some women experiencing recurrent spontaneous abortions. The ability of PSG 11 to influence the secretion of IL-10 suggests that PSG11 may contribute to the local modulation of the inflammatory T helper-1 response seen in the endometrium of these women.