Macrophages and Apoptotic Cell Clearance During Pregnancy
Article first published online: 16 MAR 2004
American Journal of Reproductive Immunology
Volume 51, Issue 4, pages 275–282, April 2004
How to Cite
Abrahams, V. M., Kim, Y. M., Straszewski, S. L., Romero, R. and Mor, G. (2004), Macrophages and Apoptotic Cell Clearance During Pregnancy. American Journal of Reproductive Immunology, 51: 275–282. doi: 10.1111/j.1600-0897.2004.00156.x
- Issue published online: 16 MAR 2004
- Article first published online: 16 MAR 2004
- Submitted November 15, 2002; accepted December 8, 2003.
Background: During implantation, apoptosis is critical for the appropriate tissue remodeling of the maternal decidua and invasion of the developing embryo, yet the regulation of apoptosis is also imperative for a successful pregnancy. The quick and effective removal of apoptotic cells by tissue macrophages represents an essential process, which prevents the release of self-antigens, and in the case of pregnancy, paternal alloantigens.
Methods of study: Recent studies have shown that the process of apoptotic cell clearance is not a neutral event, but rather an active one that induces macrophage production of anti-inflammatory cytokines and survival factors. Apoptotic cell clearance is, therefore, necessary for the resolution of inflammatory conditions, which during pregnancy could have lethal consequences.
Conclusions: The function of the maternal immune system during implantation and throughout pregnancy is, therefore, an important area of investigation. This review will discuss the role of decidual macrophages in apoptotic cell clearance during pregnancy.