Localization of Mast Cells in Endometrial Cysts


Address reprint requests to Hiroyuki Fujiwara, Department of Gynecology, Omiya Medical Center, Jichi Medical School, 1-847, Amanuma-cho, Saitama, 330-8503, Japan.
E-mail: fujiwara@jichi.ac.jp


Problem:   Although the presence of mast cells in endometriosis lesions has been reported, there have been no reports of their pathological localization in ovarian endometrial cysts.

Methods of study:  The localization of mast cells in ovarian endometrial cysts were investigated using hematoxyline and eosin and toluidine blue staining with light microscopy, immunohistochemical c-kits, and electron microscopy.

Results:  Mast cells were identified in endometrial cyst tissues. Few mast cells were localized in the endometrial stroma, which is characteristic of endometrial gland-like regions. Many mast cells were noted around blood vessels and the interstitium with fibrosis, that is, the fibrotic interstitium of endometrial cysts.

Conclusions:  Mast cells may be involved in the development and progression of endometriosis. Localization of mast cells suggests a particularly close relationship with fibrosis and adhesion.