Perlecan and Syndecan-4 in Uterine Tissues during the Early Pregnancy in Mice
Article first published online: 24 JUN 2004
American Journal of Reproductive Immunology
Volume 52, Issue 1, pages 53–59, July 2004
How to Cite
San Martin, S., Soto-Suazo, M. and Zorn, T. M. T. (2004), Perlecan and Syndecan-4 in Uterine Tissues during the Early Pregnancy in Mice. American Journal of Reproductive Immunology, 52: 53–59. doi: 10.1111/j.1600-0897.2004.00182.x
- Issue published online: 24 JUN 2004
- Article first published online: 24 JUN 2004
- Submitted 4 March, 2004; accepted 4 March, 2004.
Problem: During early pregnancy in mice, there is recruitment of specific immune cells, remodeling of the endometrium, cell differentiation and synthesis of new molecules.
Method of study: Immunohistochemistry was used to determine the distribution of perlecan and syndecan-4 in the uteri before and after embryo implantation.
Results: During pre-implantation, perlecan was identified in basement membranes and extracellular spaces of the endometrial stroma. In contrast, expression of syndecan-4 was quite weak. In the peri-implantation period, perlecan remained in the basement membranes, and it was no longer observed in the stroma and it was identified in the embryonic cells. On day 4 of pregnancy, syndecan-4 increased in the fibroblasts of the subepithelial stroma. After implantation, syndecan-4 was pronounced in pre-decidual and mature decidual cells.
Conclusions: The coordinate balance between the pre- and post-implantation periods suggests a role of these two molecules in the adaptive modification of the uterine microenvironment to receive and implant the embryo.