Leukemia Inhibitory Factor: An Important Regulator of Endometrial Function
Article first published online: 26 JUL 2004
American Journal of Reproductive Immunology
Volume 52, Issue 2, pages 97–105, August 2004
How to Cite
Kondera-Anasz, Z., Sikora, J. and Mielczarek-Palacz, A. (2004), Leukemia Inhibitory Factor: An Important Regulator of Endometrial Function. American Journal of Reproductive Immunology, 52: 97–105. doi: 10.1111/j.1600-0897.2004.00204.x
- Issue published online: 26 JUL 2004
- Article first published online: 26 JUL 2004
- Submitted February 18, 2004; revised May 14, 2004; accepted May 18, 2004.
- leukemia inhibitory factor
Problem: Leukemia inhibitory factor (LIF) is multifunctional cytokine that displays biological activities in different cells, including endometrial cells. The aim of this study is to describe implications of LIF on a physiological function of endometrium.
Method of study: The role of LIF in the endometrial function is reviewed and summarized from the available literature.
Results: LIF plays an important role in a physiological function of endometrium. In human endometrial LIF expression depends on cellular localizations, steroid hormones, menstrual stages and a local cytokine network. Stronger LIF expression exists in an endometrial epithelium during a luteal phase of the menstrual cycle, which coincides with the time of an implantation. The impairments of the endometrial LIF expression may play a significant role in the pathological processes involving implantation and the infertility.
Conclusions: There is a substantial evidence that LIF is a potential regulator of the endometrial function and might be one of the factors that play a key role in human reproduction.