Pregnancy Outcome in Recurrent Aborters is Not Influenced by Chlamydia IgA and/or G
Article first published online: 24 JAN 2005
American Journal of Reproductive Immunology
Volume 53, Issue 1, pages 50–53, January 2005
How to Cite
Sugiura-Ogasawara, M., Ozaki, Y., Nakanishi, T., Kumamoto, Y. and Suzumori, K. (2005), Pregnancy Outcome in Recurrent Aborters is Not Influenced by Chlamydia IgA and/or G. American Journal of Reproductive Immunology, 53: 50–53. doi: 10.1111/j.1600-0897.2004.00242.x
- Issue published online: 24 JAN 2005
- Article first published online: 24 JAN 2005
- Submitted June 25, 2004; revised November 16, 2004; accepted November 29, 2004.
- Chlamydia DNA;
- chlamydia IgA or IgG;
- complement 3;
- recurrent miscarriage
Problem: It is unclear whether chlamydia infection influences the miscarriage rate and immunological factors in patients with recurrent miscarriage.
Method of study: Chlamydia DNA, IgA and IgG to Chlamydia trachomatis, natural killer cell activity, complement 3 (C3), C4, hemolytic complement, antinuclear antibodies, antiphospholipid antibodies, prolactin, activated partial thromboplastin time, prothrombin time and fibrinogen were examined in 504 patients with a history of two or more consecutive first-trimester miscarriages. Subsequent pregnancy outcomes were compared between cases with and without antibodies to C. trachomatis.
Results: Totals of 10 of 30 and 48 of 201 patients receiving no medication miscarried subsequently with and without chlamydia infection. Chlamydia IgA and/or IgG were associated with a high level of C3 but not other immunological and coagulatory parameters.
Conclusion: Antibodies to C. trachomatis do not influence subsequent pregnancy outcome in patients with a history of recurrent miscarriage.