Epithelial Cells in the Female Reproductive Tract: a Central Role as Sentinels of Immune Protection
Article first published online: 8 FEB 2005
American Journal of Reproductive Immunology
Volume 53, Issue 2, pages 65–76, February 2005
How to Cite
Wira, C. R., Grant-Tschudy, K. S. and Crane-Godreau, M. A. (2005), Epithelial Cells in the Female Reproductive Tract: a Central Role as Sentinels of Immune Protection. American Journal of Reproductive Immunology, 53: 65–76. doi: 10.1111/j.1600-0897.2004.00248.x
- Issue published online: 8 FEB 2005
- Article first published online: 8 FEB 2005
- Submitted November 3, 2004; revised November 30, 2004; accepted December 9, 2004.
- Epithelial cells;
- transepithelial resistance;
The continued presence of bacterial and viral antigens in the lumen of the vagina coupled with the periodic presence of antigens in the lumena of the upper reproductive tract provide an ongoing challenge that can compromise female reproductive health and threaten life. Separating underlying tissues from luminal antigens, polarized epithelial cells of the cervix, uterus and Fallopian tubes have evolved to protect against potential pathogens. Once thought to function exclusively by providing a crucial barrier, mucosal epithelial cells are now known to function as sentinels that recognize antigens, respond in ways that lead to bacterial and viral killing, as well as signal to underlying immune cells when pathogenic challenge exceeds their protective capacity. Unique to epithelial cells of the female reproductive tract is the regulatory control of the female sex hormones. Acting both directly and indirectly through underlying stromal cells, estradiol and progesterone regulate epithelial cell innate and adaptive immune functions to protect against potential pathogens while providing an environment that supports an allogeneic fetus. In this article, we will outline how polarized epithelial cells function as the first line of defense against potential pathogens in the female reproductive tract.