The Factor V Leiden and the G20210A Prothrombin Gene Mutations are Rare in Women with Fetal Death
Article first published online: 9 JUN 2005
American Journal of Reproductive Immunology
Volume 54, Issue 1, pages 1–4, July 2005
How to Cite
Sullivan, A. E., Nelson, L., Rice, J. A., Flint Porter, T., Ware Branch, D. and Silver, R. M. (2005), The Factor V Leiden and the G20210A Prothrombin Gene Mutations are Rare in Women with Fetal Death. American Journal of Reproductive Immunology, 54: 1–4. doi: 10.1111/j.1600-0897.2005.00277.x
- Issue published online: 9 JUN 2005
- Article first published online: 9 JUN 2005
- Submitted December 2, 2004; revised February 28, 2005; accepted March 10, 2005.
- Adverse pregnancy outcomes;
- fetal demise;
Problem: To determine if there is an association between two commonly inherited thrombophilias, the factor V Leiden and the G20210A prothrombin mutations, and fetal death.
Method of study: We used a case–control study design to compare the frequencies of these mutations in women with fetal death and controls. Fetal death was the intrauterine death of the conceptus ≥10 weeks gestation. Controls had one live birth, no miscarriages, and no fetal death. Results were compared using chi square analysis.
Results: One hundred and seventy-five cases and controls were identified. There were 4.6% of cases and 3.8% of controls heterozygous for the factor V Leiden mutation (NS), and 1.3% of cases and 1.7% of controls heterozygous for the prothrombin mutation (NS).
Conclusion: In our population, neither the factor V Leiden nor the G20210A prothrombin mutations are associated with fetal death. Further evidence is required before routine screening for these mutations can be recommended.