Altered Immunophenotypic Parameters in Infertile Women. Possible Role of Herpes Viremia
Article first published online: 5 AUG 2005
American Journal of Reproductive Immunology
Volume 54, Issue 2, pages 101–111, August 2005
How to Cite
Thomas, D., Michou, V., Moustakarias, T., Aleporou, V., Matzavinos, T., Mitsakos-Barbagiannis, K., Kalofoutis, A. and Tsilivakos, V. (2005), Altered Immunophenotypic Parameters in Infertile Women. Possible Role of Herpes Viremia. American Journal of Reproductive Immunology, 54: 101–111. doi: 10.1111/j.1600-0897.2005.00293.x
- Issue published online: 5 AUG 2005
- Article first published online: 5 AUG 2005
- Submitted December 16, 2004; revised April 20, 2005; accepted April 25, 2005.
- herpes viremia;
- natural killer cells;
- white blood cells
Purpose of this study was to reveal any alteration in peripheral blood lymphocytic concentrations of a large cohort of infertile women and to investigate the possible role of herpes viremia in the peripheral immunostimulation.
Method of study
The immunophenotypic characteristics and the presence of herpes viruses DNA in the peripheral blood of 168 infertile women were studied.
Peripheral CD56+/CD16+ natural killer (NK) cell concentration, CD56+/CD16− NK cell concentration, white blood cell (WBC) concentration and lymphocyte concentration were statistically correlated to herpes viremia. Epstein–Barr virus (EBV) viremia is related with a limited reduction of CD56+/CD16− cell levels in the peripheral blood of infertile women with regard to the rest of herpes viruses. High T-lymphocyte concentration, CD4+ T-cell concentration and CD8+ T-cell concentration was observed in women positive for three different kinds of herpes viruses (triple viremia) in the peripheral blood.
Assuming that all women under study remained asymptomatic, these data suggest that subclinical herpesvirus viremia may be an important cause of peripheral immunostimulation in women with a history of infertility.