The Role of Mannose Receptor on HIV-1 Entry into Human Spermatozoa
Article first published online: 8 MAR 2006
American Journal of Reproductive Immunology
Volume 55, Issue 4, pages 241–245, April 2006
How to Cite
Cardona-Maya, W., López-Herrera, A., Velilla-Hernández, P., Rugeles, M. T. and Cadavid, Á. P. (2006), The Role of Mannose Receptor on HIV-1 Entry into Human Spermatozoa. American Journal of Reproductive Immunology, 55: 241–245. doi: 10.1111/j.1600-0897.2005.00340.x
- Issue published online: 8 MAR 2006
- Article first published online: 8 MAR 2006
- Submitted April 13, 2005;revised September 6, 2005; accepted October 13, 2005.
- Human immunodeficiency virus;
- mannose receptor;
In this opinion article we consider the possibility that human spermatozoa have receptors for human immunodeficiency virus-1 (HIV-1). It is clear that sperm cells have the potential for transmitting HIV-1, but the mechanisms responsible for spreading or the virus by this vector are not known. In contrast to the traditional HIV-1 target cells, spermatozoa do not express CD4 receptors or the CCR5/CXCR4 co-receptors. Recent evidence indicates that astrocytes, which also do not express these molecules, can be infected with HIV-1 through the mannose receptor. Furthermore, a 160-kDa sperm receptor that interacts with the HIV gp 120 has been described. Therefore, we hypothesize that the mannose receptor, of 165–175 kDa, is the receptor that HIV-1 uses to invade spermatozoa, which could lead to both vertical and horizontal transmission of HIV-1.